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Pharmacogenomics

Pharmacogenomics(PGx)

“A TEST THAT CAN TAILOR YOUR THERAPY”

The United States suffers from the severe health issue of adverse drug events (ADEs), which affect those taking medication of any level, dosage, or quantity. To fight the human health factors and financial weight of ADEs, MicroGen Health uses modern pharmacogenomics genomic testing. This panel presents our clients with clues to how their bodies may respond to different therapeutic drugs. This is done by examining the influence of various genetic factors concerning absorption, distribution, metabolism, elimination, and action of therapeutic drug treatment.

We offer our precise panel results to clients and their medical providers as guidelines for future recommendations of appropriate drugs and dosages. This, in turn, increases therapeutic efficacy while minimizing possible future ADEs. Recent genetic research has shown that a significant portion of the patient population is dosing ineffectively due, at least in part, to a genetic mismatch between the metabolism and medication.

This test will help inform clients of their genetic makeup, which, coupled with modifications to their lifestyle and nutrition, may modify their drug usage. This information leads to not only higher-quality lives but to the actual prevention of life-threatening drug missteps. The USFDA has made this panel mandatory for certain drugs to ensure safety and efficacy. When everything in life can be customized, why not customize your therapy?

Genes

Pharmacogenomic panel covers 30 genetic markers

Cardiovascular panel

This is an 10-gene panel customized to cardiovascular medications such as anti-coagulants, anti-platelet agents and statins. The genes covered are:

10 genes
  • ApoE
  • CYP2C19
  • CYP2C9
  • VKORC1
  • CYP4F2
  • F2
  • F5
  • MTHFR
  • SLCO1B1
  • UGT2B15

Psychiatric panel

This is a 6-gene panel customized for anti-psychotic and anti-depressant medications. Genes covered are:

6 genes
  • ANKK1
  • BDNF
  • CACNA1C
  • COMT
  • GRIK4
  • OPRK1

Pain management and deaddiction panel

This is an 2-gene panel customized for opioids and non-opioids. The genes covered are:

2 genes
  • CYP2B6
  • CYP2D6

Oncology Pharmacogenomics panel

This is a 4-gene panel customized for anti-cancer agents. The genes covered are:

4 genes
  • ABCB1
  • ABCG2
  • ADRA2A
  • TPMT

Comprehensive panel

This is a 8-gene panel for comprehensive pharmacogenetic testing. The genes covered are:

8 genes
  • CYP1A2
  • CYP3A4
  • CYP3A5
  • DBH
  • HTR2A
  • HTR2C
  • OPRM1
  • SLC6A3/DAT1

When & Why to do Pharmacogenomic Testing?

The earlier clients can be tested, the better. If a client is concerned about the possibility of a future diagnosis, they should reach out to their primary care provider for guidance. That provider will most likely review certain personal history and background medical information to determine if testing would be appropriate. Some of the reasons for ordering this test include:

  • To identify the medication that is suitable for you
  • To adjust the dose of medication
  • To prescribe alternate therapy
  • To prevent the adverse reactions associated with certain medication

Steps involved in Pharmacogenomic Testing

Sample Collection and Transport

Primary physicians should first conduct a pre-test genetic counseling session with their patients before referring them for testing. This is so all the appropriate questions are answered about the potential benefits and limitations of the test. There will then be a trained laboratory technician that will collect a whole blood sample or buccal swab of the client into a specific testing container. That sample will then be sent to our labs in a safe, temperature-controlled setting.s

Test Procedure

Genomic DNA will be carefully extracted from the collected sample by our expert technicians using the latest technology. Our lab will then assess the quality and quantity of the sample for genetic markers using Next Generation Sequence. The genetic markers will be evaluated using Taqman OpenArray PGX Express panel on a real-time PCR machine, “QuantStudioTM12K Flex”. The genetic data will be processed further using Bioinformatics tools to understand its impact on the drug metabolizer phenotype.

Test Report

All test reports will be shared with the concerned physician or medical professional, who will guide the client on the suitability of specific medications and their respective dosage schedules.

Customer Service

At MicroGen, we strive to provide only evidence-backed test results using experienced technicians and experts with the latest technology. We protect our client’s privacy according to industry standards and seek to have a professional customer interaction each and every time. If you would like to begin your test or have any other questions, please reach out to our team using our contact page. Thank you for considering MicroGen Health for your health care diagnostics.

Pharmacogenomic Tests with Therapeutic Management Recommendations

Medication name Gene
Amphetamine CYP2D6
Aripiprazole CYP2D6
Atomoxetine CYP2D6
Azathioprine TPMT
Brexpiprazole CYP2D6
Brivaracetam CYP2C19
Celecoxib CYP2C9
Citalopram CYP2C19
Clobazam CYP2C19
Clopidogrel CYP2C19
Clozapine CYP2D6
Codeine CYP2D6
Duetetrabenazine CYP2D6
Dronabinol CYP2C9
Eliglustat CYP2D6
Erdafitinib CYP2C9
Flibanserin CYP2C19
Flurbiprofen CYP2C9
Gefitinib CYP2D6
Iloperidone CYP2D6
Lofexidine CYP2D6
Meclizine CYP2D6
Meloxicam CYP2C9
Metoclopramide CYP2D6
Mercaptopurine TPMT
Oliceridine CYP2D6
Pantoprazole CYP2C19
Pimozide CYP2D6
Piroxicam CYP2C9
Pitolisant CYP2D6
Propafenone CYP2D6
Siponomod CYP2C9
Tacrolimus CYP3A5
Tetrabenazine CYP2D6
Thioguanine TPMT
Thioridazine CYP2D6
Tramadol CYP2D6
Valbenazine CYP2D6
Venlafaxine CYP2D6
Vortioxetine CYP2D6
Warfarin CYP2C9, VKORC1, CYP4F2

Pharmacogenomic Tests to Determine Safety with Medications

Drug Gene
Carvedilol CYP2D6
Cevimeline CYP2D6
Codeine CYP2D6
Efavirenz CYP2B6
Perphenazine CYP2D6
Simvastatin SLCO1B1
Tolterodine CYP2D6
Voriconazole CYP2C19
  • Specimen requirements

    Buccal swab

  • Turn around time:

    3-4 weeks