Pharmacogenomics

Pharmacogenomics(PGx)

“A TEST THAT CAN TAILOR YOUR THERAPY”

The United States suffers from the severe health issue of adverse drug events (ADEs), which affect those taking medication of any level, dosage, or quantity. To fight the human health factors and financial weight of ADEs, MicroGen Health uses modern pharmacogenomics genomic testing. This panel presents our clients with clues to how their bodies may respond to different therapeutic drugs. This is done by examining the influence of various genetic factors concerning absorption, distribution, metabolism, elimination, and action of therapeutic drug treatment.

We offer our precise panel results to clients and their medical providers as guidelines for future recommendations of appropriate drugs and dosages. This, in turn, increases therapeutic efficacy while minimizing possible future ADEs. Recent genetic research has shown that a significant portion of the patient population is dosing ineffectively due, at least in part, to a genetic mismatch between the metabolism and medication.

This test will help inform clients of their genetic makeup, which, coupled with modifications to their lifestyle and nutrition, may modify their drug usage. This information leads to not only higher-quality lives but to the actual prevention of life-threatening drug missteps. The USFDA has made this panel mandatory for certain drugs to ensure safety and efficacy. When everything in life can be customized, why not customize your therapy?

Genes

Pharmacogenomic panel covers 60 genetic markers

Cardiovascular panel

This is an 11-gene panel customized to cardiovascular medications such as anti-coagulants, anti-platelet agents and statins.

11 genes
  • ApoE
  • CYP2C19
  • CYP2C9
  • VKORC1
  • VKORC1
  • CYP2D6
  • CYP3A4
  • F2
  • F5
  • MTHFR
  • SLCO1B1

Psychiatric panel

This is a 17-gene panel customized for anti-psychotic and anti-depressant medications.

17 genes
  • ANKK1
  • ApoE
  • BDNF
  • CACNA1C
  • COMT
  • CYP1A2
  • CYP2C19
  • CYP2D6
  • CYP2C9
  • CYP3A4
  • GRIK1
  • GRIK4
  • GRIN2B
  • HTR2A
  • HTR2C
  • OPRD1
  • OPRK1

Pain management and deaddiction panel

This is an 8-gene panel customized for opioids and non-opioids.

8 genes
  • CYP1A2
  • CYP2B6
  • CYP2C19
  • CYP2C9
  • CYP2D6
  • CYP3A4
  • CYP3A5
  • OPRM1

Oncology Pharmacogenomics panel

This is a 5-gene panel customized for anti-cancer agents.

5 genes
  • ABCG2
  • ADRA2A
  • CYP3A4
  • CYP3A5
  • TPMT

Comprehensive panel

This is a 30-gene panel for comprehensive pharmacogenetic testing.

30 genes
  • ABCG2
  • ADRA2A
  • ANKK1
  • ApoE
  • BDNF
  • CACNA1C
  • COMT
  • CYP1A2
  • CYP2B6
  • CYP2C19
  • CYP2C9
  • CYP4F2
  • CYP2D6
  • CYP3A4
  • CYP3A5
  • DBH
  • F2
  • F5
  • MTHFR
  • GRIK1
  • GRIK4
  • GRIN2B
  • HTR2A
  • HTR2C
  • OPRD1
  • OPRK1
  • OPRM1
  • SLCO1B1
  • TPMT

When and Why to do Pharmacogenomic Testing?

The earlier clients can be tested, the better. If a client is concerned about the possibility of a future diagnosis, they should reach out to their primary care provider for guidance. That provider will most likely review certain personal history and background medical information to determine if testing would be appropriate. Some of the reasons for ordering this test include:

  • To identify the medication that is suitable for you
  • To adjust the dose of medication
  • To prescribe alternate therapy
  • To prevent the adverse reactions associated with certain medication

Steps involved in Pharmacogenomic Testing

Sample Collection and Transport

Primary physicians should first conduct a pre-test genetic counseling session with their patients before referring them for testing. This is so all the appropriate questions are answered about the potential benefits and limitations of the test. There will then be a trained laboratory technician that will collect a whole blood sample or buccal swab of the client into a specific testing container. That sample will then be sent to our labs in a safe, temperature-controlled setting.s

Test Procedure

Genomic DNA will be carefully extracted from the collected sample by our expert technicians using the latest technology. Our lab will then assess the quality and quantity of the sample for genetic markers using generation sequencing. The genetic markers will be evaluated using Taqman OpenArray PGX Express panel on a real-time PCR machine, “QuantStudioTM12K Flex”. The genetic data will be processed further using Bioinformatics tools to understand its impact on the drug metabolizer phenotype.

Test Report

All test reports will be shared with the concerned physician or medical professional, who will guide the client on the suitability of specific medications and their respective dosage schedules.

Customer Service

At MicroGen, we strive to provide only evidence-backed test results using experienced technicians and experts with the latest technology. We protect our client’s privacy according to industry standards and seek to have a professional customer interaction each and every time. If you would like to begin your test or have any other questions, please reach out to our team using our contact page. Thank you for considering MicroGen Health for your health care diagnostics.

Pharmacogenomic Tests with Therapeutic Management Recommendations

Medication nameGene
AmphetamineCYP2D6
AripiprazoleCYP2D6
AtomoxetineCYP2D6
AzathioprineTPMT
BrexpiprazoleCYP2D6
BrivaracetamCYP2C19
CelecoxibCYP2C9
CitalopramCYP2C19
ClobazamCYP2C19
ClopidogrelCYP2C19
ClozapineCYP2D6
CodeineCYP2D6
DuetetrabenazineCYP2D6
DronabinolCYP2C9
EliglustatCYP2D6
ErdafitinibCYP2C9
FlibanserinCYP2C19
FlurbiprofenCYP2C9
GefitinibCYP2D6
IloperidoneCYP2D6
LofexidineCYP2D6
MeclizineCYP2D6
MeloxicamCYP2C9
MetoclopramideCYP2D6
MercaptopurineTPMT
OliceridineCYP2D6
PantoprazoleCYP2C19
PimozideCYP2D6
PiroxicamCYP2C9
PitolisantCYP2D6
PropafenoneCYP2D6
SiponomodCYP2C9
TacrolimusCYP3A5
TetrabenazineCYP2D6
ThioguanineTPMT
ThioridazineCYP2D6
TramadolCYP2D6
ValbenazineCYP2D6
VenlafaxineCYP2D6
VortioxetineCYP2D6
WarfarinCYP2C9, VKORC1, CYP4F2

Pharmacogenomic Tests to Determine Safety with Medications

Drug Gene
Carvedilol CYP2D6
Cevimeline CYP2D6
Codeine CYP2D6
Efavirenz CYP2B6
Perphenazine CYP2D6
Simvastatin SLCO1B1
Tolterodine CYP2D6
Voriconazole CYP2C19
  • Specimen requirements

    Buccal swab

  • Turn around time:

    7-14 calendar days

  • CPT Codes:

    XXXXX

    NOTE: The CPT codes listed on the website are in accordance with Current Procedural Terminology, a publication of the American Medical Association. CPT codes are provided here for the convenience of our clients. Clients who bill for services should make the final decision on which codes to use.

  • Coverage:

    XXXXXXX